Researchers have developed three new antibiotics from scorpion venom and habanero peppers to combat tuberculosis and other drug-resistant pathogens. Researchers from the National Autonomous University of Mexico (UNAM) have identified new ways to combat tuberculosis and reduce bacterial resistance, developing three new antibiotics derived from scorpion venom and habanero peppers. A team led by Lourival Domingos Possani Postay, from the Institute of Biotechnology's Morelos campus, created two drugs that demonstrated efficacy against the bacterium, responsible for tuberculosis, as well as against, a microorganism that in hospital environments can cause various clinical complications, from skin infections to potentially fatal diseases such as pneumonia, meningitis, septicemia, and endocarditis. The antibiotics were derived from the venom of the scorpion, native to the state of Veracruz. The team was able to isolate two colorless molecules called benzoquinones--heterocyclic compounds that do not contain amino acids--from the arachnid's toxin.

At seventy-three, the former front man of Talking Heads is still asking questions about what it means to be alive. "When you step onstage, it's a very artificial situation," Byrne said. "To pretend it's not--that isn't being authentic." If you spend enough time wandering around downtown Manhattan, the odds are that you'll eventually encounter the musician David Byrne riding a bicycle. One day this past June, pedalling alongside Byrne from his apartment in Chelsea to the Governors Island ferry, I watched at least a dozen New Yorkers clock his profile, whipping around to squint, softly pinching the arm of their companion and whispering, "Was that . . . By then, Byrne was gone, a tuft of white hair whizzing toward the horizon. Spotting Byrne on two wheels has become a New York City rite of passage, like sussing out the best halal cart in midtown, or dropping something important onto the subway tracks. During the few months that Byrne and I spent together, I never saw him traverse the ...

Understanding socio-ecological systems requires insights from diverse stakeholder perspectives, which are often hard to access. To enable alternative, simulation-based exploration of different stakeholder perspectives, we develop the HoPeS (Human-Oriented Perspective Shifting) modelling framework. HoPeS employs agents powered by large language models (LLMs) to represent various stakeholders; users can step into the agent roles to experience perspectival differences. A simulation protocol serves as a "scaffold" to streamline multiple perspective-taking simulations, supporting users in reflecting on, transitioning between, and integrating across perspectives. A prototype system is developed to demonstrate HoPeS in the context of institutional dynamics and land use change, enabling both narrative-driven and numerical experiments. In an illustrative experiment, a user successively adopts the perspectives of a system observer and a researcher - a role that analyses data from the embedded land use model to inform evidence-based decision-making for other LLM agents representing various institutions. Despite the user's effort to recommend technically sound policies, discrepancies persist between the policy recommendation and implementation due to stakeholders' competing advocacies, mirroring real-world misalignment between researcher and policymaker perspectives. The user's reflection highlights the subjective feelings of frustration and disappointment as a researcher, especially due to the challenge of maintaining political neutrality while attempting to gain political influence. Despite this, the user exhibits high motivation to experiment with alternative narrative framing strategies, suggesting the system's potential in exploring different perspectives. Further system and protocol refinement are likely to enable new forms of interdisciplinary collaboration in socio-ecological simulations.

An Achilles heel of Large Language Models (LLMs) is their tendency to hallucinate non-factual statements. A response mixed of factual and non-factual statements poses a challenge for humans to verify and accurately base their decisions on. To combat this problem, we propose Highlighted Chain-of-Thought Prompting (HoT), a technique for prompting LLMs to generate responses with XML tags that ground facts to those provided in the query. That is, given an input question, LLMs would first re-format the question to add XML tags highlighting key facts, and then, generate a response with highlights over the facts referenced from the input. Interestingly, in few-shot settings, HoT outperforms vanilla chain of thought prompting (CoT) on a wide range of 17 tasks from arithmetic, reading comprehension to logical reasoning. When asking humans to verify LLM responses, highlights help time-limited participants to more accurately and efficiently recognize when LLMs are correct. Yet, surprisingly, when LLMs are wrong, HoTs tend to make users believe that an answer is correct.

The MITRE ATT&CK framework is a widely adopted tool for enhancing cybersecurity, supporting threat intelligence, incident response, attack modeling, and vulnerability prioritization. This paper synthesizes research on its application across these domains by analyzing 417 peer-reviewed publications. We identify commonly used adversarial tactics, techniques, and procedures (TTPs) and examine the integration of natural language processing (NLP) and machine learning (ML) with ATT&CK to improve threat detection and response. Additionally, we explore the interoperability of ATT&CK with other frameworks, such as the Cyber Kill Chain, NIST guidelines, and STRIDE, highlighting its versatility. The paper further evaluates the framework from multiple perspectives, including its effectiveness, validation methods, and sector-specific challenges, particularly in industrial control systems (ICS) and healthcare. We conclude by discussing current limitations and proposing future research directions to enhance the applicability of ATT&CK in dynamic cybersecurity environments.

The NAHU$^2$ project is a Franco-Mexican collaboration aimed at building the $\pi$-YALLI corpus adapted to machine learning, which will subsequently be used to develop computer resources for the Nahuatl language. Nahuatl is a language with few computational resources, even though it is a living language spoken by around 2 million people. We have decided to build $\pi$-YALLI, a corpus that will enable to carry out research on Nahuatl in order to develop Language Models (LM), whether dynamic or not, which will make it possible to in turn enable the development of Natural Language Processing (NLP) tools such as: a) a grapheme unifier, b) a word segmenter, c) a POS grammatical analyser, d) a content-based Automatic Text Summarization; and possibly, e) a translator translator (probabilistic or learning-based).

Species range maps (SRMs) are essential tools for research and policy-making in ecology, conservation, and environmental management. However, traditional SRMs rely on the availability of environmental covariates and high-quality species location observation data, both of which can be challenging to obtain due to geographic inaccessibility and resource constraints. We propose a novel approach combining millions of citizen science species observations with textual descriptions from Wikipedia, covering habitat preferences and range descriptions for tens of thousands of species. Our framework maps locations, species, and text descriptions into a common space, facilitating the learning of rich spatial covariates at a global scale and enabling zero-shot range estimation from textual descriptions. Evaluated on held-out species, our zero-shot SRMs significantly outperform baselines and match the performance of SRMs obtained using tens of observations. Our approach also acts as a strong prior when combined with observational data, resulting in more accurate range estimation with less data. We present extensive quantitative and qualitative analyses of the learned representations in the context of range estimation and other spatial tasks, demonstrating the effectiveness of our approach.

As events progress, news articles often update with new information: if we are not cautious, we risk propagating outdated facts. In this work, we hypothesize that linguistic features indicate factual fluidity, and that we can predict which facts in a news article will update using solely the text of a news article (i.e. not external resources like search engines). We test this hypothesis, first, by isolating fact-updates in large news revisions corpora. News articles may update for many reasons (e.g. factual, stylistic, narrative). We introduce the NewsEdits 2.0 taxonomy, an edit-intentions schema that separates fact updates from stylistic and narrative updates in news writing. We annotate over 9,200 pairs of sentence revisions and train high-scoring ensemble models to apply this schema. Then, taking a large dataset of silver-labeled pairs, we show that we can predict when facts will update in older article drafts with high precision. Finally, to demonstrate the usefulness of these findings, we construct a language model question asking (LLM-QA) abstention task. We wish the LLM to abstain from answering questions when information is likely to become outdated. Using our predictions, we show, LLM absention reaches near oracle levels of accuracy.

Recent advancements of large language models (LLMs) have led to claims of AI surpassing humans in natural language processing (NLP) tasks such as textual understanding and reasoning. This work investigates these assertions by introducing CAIMIRA, a novel framework rooted in item response theory (IRT) that enables quantitative assessment and comparison of problem-solving abilities of question-answering (QA) agents: humans and AI systems. Through analysis of over 300,000 responses from ~70 AI systems and 155 humans across thousands of quiz questions, CAIMIRA uncovers distinct proficiency patterns in knowledge domains and reasoning skills. Humans outperform AI systems in knowledge-grounded abductive and conceptual reasoning, while state-of-the-art LLMs like GPT-4 and LLaMA show superior performance on targeted information retrieval and fact-based reasoning, particularly when information gaps are well-defined and addressable through pattern matching or data retrieval. These findings highlight the need for future QA tasks to focus on questions that challenge not only higher-order reasoning and scientific thinking, but also demand nuanced linguistic interpretation and cross-contextual knowledge application, helping advance AI developments that better emulate or complement human cognitive abilities in real-world problem-solving.

We introduce the Faetar Automatic Speech Recognition Benchmark, a benchmark corpus designed to push the limits of current approaches to low-resource speech recognition. Faetar, a Franco-Proven\c{c}al variety spoken primarily in Italy, has no standard orthography, has virtually no existing textual or speech resources other than what is included in the benchmark, and is quite different from other forms of Franco-Proven\c{c}al. The corpus comes from field recordings, most of which are noisy, for which only 5 hrs have matching transcriptions, and for which forced alignment is of variable quality. The corpus contains an additional 20 hrs of unlabelled speech. We report baseline results from state-of-the-art multilingual speech foundation models with a best phone error rate of 30.4%, using a pipeline that continues pre-training on the foundation model using the unlabelled set.